Biomedical scientists tend to focus on only a small fraction of the proteins encoded by the human genome despite overwhelming genetic evidence that many understudied proteins are important for human disease. One of the best ways to interrogate the function of a protein and to determine its relevance as a drug target is by using a pharmacological modulator, such as a chemical probe or an antibody. If these tools were available for most human proteins, it should be possible to translate the tremendous advances in genomics into a greater understanding of human health and disease, and catalyze the creation of innovative new medicines. Target 2035 is a global federation for developing and applying new technologies with the goal of creating chemogenomic libraries, chemical probes, and/or functional antibodies for the entire proteome.

中文翻译：

---

2035年目标：探测人类蛋白质组。

尽管有大量的遗传学证据表明，许多被研究不足的蛋白质对人类疾病很重要，但生物医学科学家往往只关注人类基因组编码的蛋白质的一小部分。询问蛋白质功能并确定其与药物靶标相关性的最佳方法之一是使用药理调节剂，例如化学探针或抗体。如果这些工具可用于大多数人类蛋白质，则应该有可能将基因组学的巨大进步转化为对人类健康和疾病的更深入了解，并促进创新药物的创造。Target 2035是一个全球联合会，旨在开发和应用新技术，以期为整个蛋白质组创建化学基因组文库，化学探针和/或功能性抗体。