The fascinating and dangerous colored pathogens contain unique chemically pigmented molecules, which give varied and efficient assistance as virulence factors to the crucial reproduction and growth of microbes. Therefore, multiple novel strategies and inhibitors have been developed in recent years that target virulence factor pigments. However, despite the importance and significance of this topic, it has not yet been comprehensively reviewed. Moreover, research groups around the world have made successful progress against antibacterial infections by targeting pigment production, including our serial works on the discovery of CrtN inhibitors against staphyloxanthin production in Staphylococcus aureus. On the basis of the previous achievements and recent progress of our group in this field, this article will be the first comprehensive review of pigment inhibitors against colored pathogens, especially S. aureus infections, and this article includes design strategies, representative case studies, advantages, limitations, and perspectives to guide future research.

中文翻译：

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靶向毒力因子作为一种抗菌方法：颜料抑制剂。

令人着迷且危险的彩色病原体包含独特的化学色素分子，它们作为毒力因子，可为微生物的关键繁殖和生长提供各种有效的帮助。因此，近年来已经开发出多种针对毒力因子颜料的新型策略和抑制剂。但是，尽管该主题很重要，但尚未对其进行全面的审查。此外，世界各地的研究小组已经通过针对色素的产生，在抗细菌感染方面取得了成功的进展，包括我们在金黄色葡萄球菌中发现针对葡萄球菌黄素的CrtN抑制剂的系列研究工作。。在我们小组在此领域的先前成就和最新进展的基础上，本文将是针对有色病原体，尤其是金黄色葡萄球菌感染的色素抑制剂的首次综合综述，包括设计策略，代表性案例研究，优势，局限性和观点来指导未来的研究。