YAP and TAZ: a signalling hub of the tumour microenvironment.,Nature Reviews Cancer

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YAP and TAZ: a signalling hub of the tumour microenvironment.
Nature Reviews Cancer ( IF 72.5 ) Pub Date : 2019-08-01 , DOI: 10.1038/s41568-019-0168-y
Francesca Zanconato ₁ , Michelangelo Cordenonsi ₁ , Stefano Piccolo _{1,

2}

Affiliation

YAP and TAZ are transcriptional activators pervasively induced in several human solid tumours and their functions in cancer cells are the focus of intense investigation. These studies established that YAP and TAZ are essential to trigger numerous cell-autonomous responses, such as sustained proliferation, cell plasticity, therapy resistance and metastasis. Yet tumours are complex entities, wherein cancer cells are just one of the components of a composite "tumour tissue". The other component, the tumour stroma, is composed of an extracellular matrix with aberrant mechanical properties and other cell types, including cancer-associated fibroblasts and immune cells. The stroma entertains multiple and bidirectional interactions with tumour cells, establishing dependencies essential to unleash tumorigenesis. The molecular players of such interplay remain partially understood. Here, we review the emerging role of YAP and TAZ in choreographing tumour-stromal interactions. YAP and TAZ act within tumour cells to orchestrate responses in stromal cells. Vice versa, YAP and TAZ in stromal cells trigger effects that positively feed back on the growth of tumour cells. Recognizing YAP and TAZ as a hub of the network of signals exchanged within the tumour microenvironment provides a fresh perspective on the molecular principles of tumour self-organization, promising to unveil numerous new vulnerabilities.

中文翻译：

YAP和TAZ：肿瘤微环境的信号枢纽。

YAP和TAZ是在几种人类实体瘤中普遍诱导的转录激活因子，它们在癌细胞中的功能是广泛研究的重点。这些研究证实，YAP和TAZ对于触发众多细胞自主反应至关重要，例如持续增殖，细胞可塑性，治疗抗性和转移。然而，肿瘤是复杂的实体，其中癌细胞只是复合“肿瘤组织”的组成部分之一。另一个成分是肿瘤基质，由具有异常机械特性的细胞外基质和其他细胞类型组成，包括与癌症相关的成纤维细胞和免疫细胞。基质与肿瘤细胞进行多种双向相互作用，建立了释放肿瘤发生必不可少的依赖性。这种相互作用的分子作用仍然是部分理解的。在这里，我们回顾了YAP和TAZ在编排肿瘤-基质相互作用中的新兴作用。YAP和TAZ在肿瘤细胞内起作用，以协调基质细胞的反应。反之亦然，基质细胞中的YAP和TAZ会触发积极反馈肿瘤细胞生长的效应。将YAP和TAZ识别为肿瘤微环境内交换信号网络的枢纽，为肿瘤自组织的分子原理提供了崭新的视角，有望揭示许多新的漏洞。基质细胞中的YAP和TAZ触发可积极反馈肿瘤细胞生长的效应。将YAP和TAZ识别为肿瘤微环境内交换信号网络的枢纽，为肿瘤自组织的分子原理提供了崭新的视角，有望揭示许多新的漏洞。基质细胞中的YAP和TAZ触发可积极反馈肿瘤细胞生长的效应。将YAP和TAZ识别为肿瘤微环境内交换信号网络的枢纽，为肿瘤自组织的分子原理提供了崭新的视角，有望揭示许多新的漏洞。

更新日期：2019-11-18

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