The effect of nomegestrol acetate/estradiol (NOMAC/E2) on clitoral and uterine vascularization has never been evaluated. We aimed to investigate, in women consulting for contraceptive needs, the possible changes in clitoral and uterine arteries hemodynamic parameters after 6 months treatment with NOMAC/E2 as compared with other hormonal contraceptives (HCs). In this observational, prospective pilot study, ten women were enrolled. Color Doppler ultrasound was performed on the clitoral and uterine arteries at baseline and after 6 months treatment with NOMAC/E2 (n = 5) or other HCs (n = 5). NOMAC/E2 did not exert any significant effect on clitoral vascular resistance expressed by the pulsatility index (PI); conversely, treatment with other HCs significantly increased this parameter (p = 0.04). The change in clitoral PI between the two groups retained a statistically significant difference even after adjusting for age. In the NOMAC/E2 group, at follow-up, uterine artery PI and acceleration were significantly reduced (p = 0.04), whereas no significant differences were observed in the HCs group; however, the change in uterine artery parameters did not differ significantly between the two groups. NOMAC/E2, differently from other COCs, does not negatively alter the vascular resistance of clitoral arteries and appears as a good contraceptive choice to protect both cardiovascular and sexual health.

从未评估过醋酸诺美孕酮/雌二醇（NOMAC / E2）对阴蒂和子宫血管形成的作用。我们旨在研究接受避孕药具需求的女性，与其他激素类避孕药（HCs）相比，用NOMAC / E2治疗6个月后阴蒂和子宫动脉血流动力学参数可能发生变化。在这项观察性，前瞻性先导研究中，招募了十名妇女。彩色多普勒超声，是在以基线阴蒂和子宫动脉和进行6个月后治疗NOMAC / E2（Ñ  = 5）或其它碳氢化合物（Ñ  = 5）。NOMAC / E2对搏动指数（PI）表示的阴蒂血管阻力没有显着影响；相反，使用其他HC进行治疗会大大增加该参数（p  = 0.04）。即使调整了年龄，两组之间的阴蒂PI的变化仍保持统计学上的显着差异。在随访中，NOMAC / E2组子宫动脉的PI和加速度显着降低（p  = 0.04），而HCs组则没有显着差异。然而，两组的子宫动脉参数变化无明显差异。与其他COC不同，NOMAC / E2不会负面改变阴蒂动脉的血管阻力，并且是保护心血管和性健康的良好避孕选择。