Study Design Prospective case series. Objective Investigate the association of testosterone and thyroid-stimulating hormone (TSH) levels with depressive symptoms in women after spinal cord injury (SCI). Setting Community SCI clinic. Methods Twenty-seven participants were enrolled in this study. Total testosterone (Total T) and TSH levels as well as the Center for Epidemiological Studies Depression Scale (CES-D) survey and monthly sexual activity were obtained from only 20 participants. Pearson's correlations were used to assess the relationship between age, time from injury, Total T level, TSH level, and CES-D total score. Follow-up analyses investigating the role of monthly sexual activity was also explored. Results Participants' average age and time from injury was 44.4 ± 12.7 years old and 11.7 ± 8.89 years, respectively. Low Total T was observed in four participants and one of those participant's presented with low TSH as well. Nine women were classified as "at risk for clinical depression" on the CES-D (total score >15). Pearson's correlations revealed a significant association between time from injury and TSH (r = .536, p = .015), as well as CES-D total score (r = -.547, p = .013). Total T was associated with CES-D total score (ρ = -.541, p = .02). Conclusions This study provides preliminary results on abnormal hormone levels and depressive symptoms in women after SCI. Twenty percent of this sample presented with low Total T, which was associated with increased depressive symptoms after accounting for time from injury. Further research is needed to investigate the impact of SCI on hormone function and mental health in women post SCI. Sponsorship Sally Rynne National Association of Women's Health Quality Award 2002.

中文翻译：

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脊髓损伤女性的甲状腺功能、睾酮水平和抑郁症状之间的相关性。

研究设计前瞻性案例系列。目的 调查脊髓损伤 (SCI) 后女性睾酮和促甲状腺激素 (TSH) 水平与抑郁症状的关系。设置社区SCI诊所。方法 27 名参与者参加了本研究。仅从 20 名参与者中获取了总睾酮 (Total T) 和 TSH 水平以及流行病学研究中心抑郁量表 (CES-D) 调查和每月性活动。Pearson 相关性用于评估年龄、受伤时间、总 T 水平、TSH 水平和 CES-D 总分之间的关​​系。还探讨了调查每月性活动的作用的后续分析。结果 参与者的平均年龄和受伤时间分别为 44.4 ± 12.7 岁和 11.7 ± 8.89 岁。在四名参与者中观察到总 T 较低，其中一名参与者的 TSH 也较低。9 名女性在 CES-D 中被归类为“有临床抑郁症风险”（总分 >15）。Pearson 相关性揭示了受伤时间与 TSH (r = .536，p = .015) 以及 CES-D 总分 (r = -.547，p = .013) 之间存在显着相关性。总 T 与 CES-D 总分相关（ρ = -.541，p = .02）。结论 本研究提供了 SCI 后女性激素水平异常和抑郁症状的初步结果。该样本中有 20% 的总 T 值较低，考虑到受伤​​时间后，这与抑郁症状的增加有关。需要进一步研究来调查 SCI 对 SCI 后女性激素功能和心理健康的影响。赞助 Sally Rynne 全国妇女健康质量协会 2002 年奖。