Invasive aspergillosis caused by intrinsically resistant non-fumigatus Aspergillus species displays a poor outcome in immunocompromised patients. The polyene antifungal amphotericin B (AmB) remains to be “gold standard” in the treatment of invasive fungal infections. Aspergillus terreus is innately resistant to AmB, in vivo and in vitro. Till now, the exact mode of action in polyene resistance is not well understood. This review highlights the underlying molecular basis of AmB resistance in A. terreus, displaying data obtained from AmB susceptible A. terreus and AmB resistant A. terreus strains. The effect of AmB on main cellular and molecular functions such as fungal respiration and stress response pathways will be discussed in detail and resistance mechanisms will be highlighted. The fungal stress response machinery seems to be a major player in the onset of AmB resistance in A. terreus.

由固有抵抗力的非烟曲霉属物种引起的侵袭性曲霉病在免疫功能低下的患者中显示出较差的结果。多烯抗真菌两性霉素B（AmB）在侵袭性真菌感染的治疗中仍然是“金标准”。在体内和体外，曲霉曲霉天生对AmB具有抗性。到目前为止，人们对多烯抗性的确切作用方式还没有完全了解。这篇综述亮点霉素抗性的潜在分子基础在土曲霉，显示从霉素易感获得的数据土曲霉和耐霉素土曲霉株。将详细讨论AmB对主要细胞和分子功能（如真菌呼吸作用和应激反应途径）的影响，并重点介绍耐药机制。真菌应激反应机制似乎是引起土壤曲霉AmB耐药的主要因素。