BACKGROUND Several studies have described a worse prognosis for right-sided colon cancer compared to left-sided. The aim of this study was to compare patterns of recurrence and survival following resection of liver metastases (LM) from right-sided (RS) versus left-sided (LS) colon cancer. METHODS Patients undergoing resection for colon cancer LM between 2000 and 2017 were analyzed. Rectal cancer, multiple primaries and unknown location were excluded. RESULTS Out of 995 patients, 686 fulfilled inclusion criteria (RS-LM = 322, LS-LM = 364). RS colon cancer had higher prevalence of metastatic lymph nodes (67.4% vs. 57.1%, P = 0.008). RS-LM were more often mucinous (16.8% vs. 8.5%, P = 0.001) and G3 (58.3% vs. 48.9%, P = 0.014). 451 (65.7%) patients experienced recurrence (RS-LM 68.9% vs. LS-LM 62.9%). In RS-LM group, recurrence was more often encephalic (2.3% vs. 0%, P = 0.029) and at multiple sites (34.2% vs. 23.5%, P = 0.012). The rate of re-resection was lower in RS-LM patients (27.9% vs. 37.5%, P = 0.024). Multivariate analysis showed RS-LM to have worse 5-year overall (35.8% vs. 51.2%, P = 0.002) and disease-free survival (26% vs. 43.6%, P = 0.002). CONCLUSIONS RS-LM is associated with worse survival and aggressive recurrences, with lower chance of re-resection.

中文翻译：

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原发肿瘤位置对接受结肠癌肝转移切除的患者复发和生存模式的影响。

背景技术一些研究描述了与左侧结肠癌相比，右侧结肠癌的预后更差。这项研究的目的是比较从右侧（RS）和左侧（LS）结肠癌切除肝转移（LM）后的复发和生存模式。方法分析2000年至2017年间因结肠癌LM切除的患者。排除了直肠癌，多个原发灶和未知的位置。结果在995例患者中，有686例符合入选标准（RS-LM = 322，LS-LM = 364）。RS结肠癌的转移淋巴结患病率更高（67.4％对57.1％，P = 0.008）。RS-LM多为粘液性（16.8％vs. 8.5％，P = 0.001）和G3（58.3％vs. 48.9％，P = 0.014）。451名（65.7％）病人复发（RS-LM 68.9％vs. LS-LM 62.9％）。在RS-LM组中，复发多发于脑部（2.3％vs. 0％，P = 0.029）和多个部位（34.2％vs. 23.5％，P = 0.012）。RS-LM患者的再切除率较低（27.9％比37.5％，P = 0.024）。多因素分析显示，RS-LM的5年总生存率较差（35.8％对51.2％，P = 0.002）和无病生存期（26％对43.6％，P = 0.002）。结论RS-LM与较差的生存率和复发性复发相关，因此再次切除的机会较低。