Magnetic iron oxide nanoparticles for disease detection and therapy,Materials Today

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Magnetic iron oxide nanoparticles for disease detection and therapy
Materials Today ( IF 21.1 ) Pub Date : 2019-12-01 , DOI: 10.1016/j.mattod.2019.06.003
Sheng Tong ₁ , Haibao Zhu ₁ , Gang Bao ₁

Affiliation

Magnetic iron oxide nanoparticles (MIONs) are among the first generation of nanomaterials that have advanced to clinic use. A broad range of biomedical techniques has been developed by combining the versatile nanomagnetism of MIONs with various forms of applied magnetic fields. MIONs can generate imaging contrast and provide mechanical/thermal energy in vivo in response to an external magnetic field, a special feature that distinguishes MIONs from other nanomaterials. These properties offer unique opportunities for nanomaterials engineering in biomedical research and clinical interventions. The past few decades have witnessed the evolution of the applications of MIONs from conventional drug delivery and hyperthermia to the regulation of molecular and cellular processes in the body. Here we review the most recent development in this field, including clinical studies of MIONs and the emerging techniques that may contribute to future innovation in medicine.

中文翻译：

用于疾病检测和治疗的磁性氧化铁纳米颗粒

磁性氧化铁纳米粒子（MION）是第一代已进入临床应用的纳米材料之一。通过将 MION 的多功能纳米磁性与各种形式的应用磁场相结合，已经开发出了广泛的生物医学技术。MION 可以产生成像对比度，并响应外部磁场而在体内提供机械/热能，这是 MION 与其他纳米材料的区别的特殊功能。这些特性为生物医学研究和临床干预中的纳米材料工程提供了独特的机会。过去的几十年见证了 MION 应用的演变，从传统的药物输送和热疗到体内分子和细胞过程的调节。在这里，我们回顾了该领域的最新发展，包括 MION 的临床研究以及可能有助于未来医学创新的新兴技术。

更新日期：2019-12-01

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