Division of amoebas, fungi, and animal cells into two daughter cells at the end of the cell cycle depends on a common set of ancient proteins, principally actin filaments and myosin-II motors. Anillin, formins, IQGAPs, and many other proteins regulate the assembly of the actin filaments into a contractile ring positioned between the daughter nuclei by different mechanisms in fungi and animal cells. Interactions of myosin-II with actin filaments produce force to assemble and then constrict the contractile ring to form a cleavage furrow. Contractile rings disassemble as they constrict. In some cases, knowledge about the numbers of participating proteins and their biochemical mechanisms has made it possible to formulate molecularly explicit mathematical models that reproduce the observed physical events during cytokinesis by computer simulations.

中文翻译：

---

细胞分裂的分子机制。

在细胞周期结束时，变形虫，真菌和动物细胞分成两个子细胞，这取决于一组古老的蛋白质，主要是肌动蛋白丝和肌球蛋白II马达。Anillin，formins，IQGAP和许多其他蛋白质通过真菌和动物细胞中的不同机制，调节肌动蛋白丝组装成位于子核之间的收缩环。肌球蛋白-II与肌动蛋白丝的相互作用产生力进行组装，然后收缩收缩环以形成切割沟。收缩环收缩时会分解。在某些情况下，有关参与蛋白数量及其生化机制的知识使人们有可能制定分子明确的数学模型，从而通过计算机模拟重现胞质分裂过程中观察到的物理事件。