Oral Delivery of Biologics for Precision Medicine,Advanced Materials

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Oral Delivery of Biologics for Precision Medicine
Advanced Materials ( IF 27.4 ) Pub Date : 2019-06-20 , DOI: 10.1002/adma.201901935
Matilde Durán‐Lobato _{1,

2,

3} , Zhigao Niu _{4,

5} , María José Alonso _{1,

2,

3}

Affiliation

The emerging field of precision medicine is rapidly growing, fostered by the advances in genome mapping and molecular diagnosis. In general, the translation of these advances into precision treatments relies on the use of biological macromolecules, whose structure offers a high specificity and potency. Unfortunately, due to their complex structure and limited ability to overcome biological barriers, these macromolecules need to be administered via injection. The scientific community has devoted significant effort to making the oral administration of macromolecules plausible thanks to the implementation of drug delivery technologies. Here, an overview of the current situation and future prospects in the field of oral delivery of biologics is provided. Technologies in clinical trials, as well as recent and disruptive delivery systems proposed in the literature for local and systemic delivery of biologics including peptides, antibodies, and nucleic acids, are described. Strategies for the specific targeting of gastrointestinal regions—stomach, small bowel, and colon—cell populations, and internalization pathways, are analyzed. Finally, challenges associated with the clinical translation, future prospects, and identified opportunities for advancement in this field are also discussed.

中文翻译：

口服精准生物制剂

随着基因组图谱和分子诊断技术的发展，精密医学的新兴领域正在迅速发展。通常，将这些进展转化为精确治疗依赖于生物大分子的使用，其结构具有很高的特异性和效力。不幸的是，由于其复杂的结构和克服生物屏障的能力有限，这些大分子需要通过注射来施用。由于实施了药物输送技术，科学界已做出巨大的努力来使大分子的口服给药变得可行。在此，概述了口服生物制剂领域的现状和未来前景。临床试验技术以及文献中提出的用于局部和全身递送包括肽，抗体和核酸在内的生物制剂的最近的和破坏性的递送系统。分析了针对胃肠道区域（胃，小肠和结肠）的细胞群体以及内化途径的策略。最后，还讨论了与临床翻译，未来前景以及已确定的在该领域中取得进展的机会相关的挑战。

更新日期：2020-04-01

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