Translatable gene therapy for lung cancer using Crispr CAS9-an exploratory review.,Cancer Gene Therapy

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Translatable gene therapy for lung cancer using Crispr CAS9-an exploratory review.
Cancer Gene Therapy ( IF 4.8 ) Pub Date : 2019-06-20 , DOI: 10.1038/s41417-019-0116-8
Jishnu Nair ₁ , Abhishek Nair ₁ , Soundaram Veerappan ₁ , Dwaipayan Sen ₁

Affiliation

Gene therapy using CRISPR Cas9 technique is rapidly gaining popularity among the scientific community primarily because of its versatility, cost-effectiveness, and high efficacy. While the laboratory-based experiments and findings making use of CRISPR as a gene editing tool are available in ample amounts, the question arises that how much of these findings are actually translatable into measures helping in combating particular disease conditions. In this review, we highlight the important studies and findings done till now in the perspective of lung cancer with an in-depth analysis of various clinical trials associated with the use of CRISPR Cas9 technology in the field of cancer research.

中文翻译：

使用 Crispr CAS9 治疗肺癌的可翻译基因治疗——探索性综述。

使用 CRISPR Cas9 技术的基因治疗在科学界迅速普及，主要是因为它的多功能性、成本效益和高效性。虽然利用 CRISPR 作为基因编辑工具的基于实验室的实验和发现有大量可用，但问题是这些发现中有多少实际上可以转化为有助于对抗特定疾病状况的措施。在这篇综述中，我们重点介绍了迄今为止从肺癌的角度所做的重要研究和发现，并深入分析了与在癌症研究领域中使用 CRISPR Cas9 技术相关的各种临床试验。

更新日期：2019-11-18

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