Mitochondrial dynamics shape the mitochondrial network and contribute to mitochondrial function and quality control. Mitochondrial fusion and division are integrated into diverse cellular functions and respond to changes in cell physiology. Imbalanced mitochondrial dynamics are associated with a range of diseases that are broadly characterized by impaired mitochondrial function and increased cell death. In various disease models, modulating mitochondrial fusion and division with either small molecules or genetic approaches has improved function. Although additional mechanistic understanding of mitochondrial fusion and division will be critical to inform further therapeutic approaches, mitochondrial dynamics represent a powerful therapeutic target in a wide range of human diseases.

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线粒体动力学及其作为治疗靶点的潜力

线粒体动力学塑造线粒体网络并有助于线粒体功能和质量控制。线粒体融合和分裂被整合到不同的细胞功能中，并对细胞生理学的变化做出反应。不平衡的线粒体动力学与一系列疾病相关，这些疾病的广泛特征是线粒体功能受损和细胞死亡增加。在各种疾病模型中，用小分子或遗传方法调节线粒体融合和分裂已经改善了功能。尽管对线粒体融合和分裂的额外机制理解对于为进一步的治疗方法提供信息至关重要，但线粒体动力学代表了广泛的人类疾病的强大治疗靶点。