BACKGROUND Heightened amygdala response to threatening cues has been repeatedly observed in borderline personality disorder (BPD). A previous report linked hyperactivation to deficient amygdala habituation to repeated stimuli, but the biological underpinnings are incompletely understood. METHODS We examined a sample of 120 patients with BPD and 115 healthy control subjects with a well-established functional magnetic resonance imaging emotional face processing task to replicate the previously reported amygdala habituation deficit in BPD and probed this neural phenotype for associations with symptom severity and early social risk exposure. RESULTS Our results confirm a significant reduction in amygdala habituation to repeated negative stimuli in BPD (pFWE = .015, peak-level familywise error [FWE] corrected for region of interest). Post hoc comparison and regression analysis did not suggest a role for BPD clinical state (pFWE > .56) or symptom severity (pFWE > .45) for this phenotype. Furthermore, deficient amygdala habituation was significantly related to increased exposure to adverse childhood experiences (pFWE = .013, region of interest corrected). CONCLUSIONS Our data replicate a prior report on deficient amygdala habituation in BPD and link this neural phenotype to early adversity, a well-established social environmental risk factor for emotion dysregulation and psychiatric illness.

中文翻译：

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边缘型人格障碍患者杏仁核对威胁性刺激的缺乏习惯与不良的童年经历有关

背景 在边缘型人格障碍 (BPD) 中反复观察到杏仁核对威胁线索的反应增强。之前的一份报告将过度激活与杏仁核习惯性缺陷与重复刺激联系起来，但其生物学基础尚不完全清楚。方法我们检查了 120 名 BPD 患者和 115 名健康对照受试者的样本，这些受试者具有完善的功能磁共振成像情绪面部处理任务，以复制先前报告的 BPD 杏仁核习惯缺陷，并探讨这种神经表型与症状严重程度和早期的关联。社会风险暴露。结果我们的结果证实了 BPD 中杏仁核对重复负刺激的习惯显着减少（pFWE = .015，针对感兴趣区域校正的峰值水平家族误差 [FWE]）。事后比较和回归分析并未表明 BPD 临床状态 (pFWE > .56) 或症状严重程度 (pFWE > .45) 对这种表型有影响。此外，杏仁核习惯不足与童年不良经历的暴露增加显着相关（pFWE = .013，感兴趣区域已校正）。结论我们的数据复制了先前关于 BPD 中杏仁核习惯缺陷的报告，并将这种神经表型与早期逆境联系起来，早期逆境是情绪失调和精神疾病的公认社会环境风险因素。感兴趣的区域已修正）。结论我们的数据复制了先前关于 BPD 中杏仁核习惯缺陷的报告，并将这种神经表型与早期逆境联系起来，早期逆境是情绪失调和精神疾病的公认社会环境风险因素。感兴趣的区域已修正）。结论我们的数据复制了先前关于 BPD 中杏仁核习惯缺陷的报告，并将这种神经表型与早期逆境联系起来，早期逆境是情绪失调和精神疾病的公认社会环境风险因素。