Personalized care of cancer patients undergoing treatment with immune checkpoint inhibitors will require approaches that can predict their susceptibility to immune-related adverse events. Understanding the role of germline genetic factors in determining individual responses to immunotherapy will deepen our understanding of immune toxicity and, importantly, it may lead to tools for identifying patients who are at risk.

中文翻译：

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与免疫检查点封锁相关的免疫相关不良事件的机制：利用种系遗传学开发个性化方法。

对接受免疫检查点抑制剂治疗的癌症患者的个性化护理将需要能够预测其对免疫相关不良事件敏感性的方法。了解种系遗传因素在确定对免疫疗法的个体反应中的作用将加深我们对免疫毒性的理解，重要的是，它可能会导致鉴定有风险的患者的工具。