Background

It is not clear whether a high level of high-density lipoprotein cholesterol (HDL-C) is associated with lower risk of atherosclerosis. It is likely that HDL-C is a double-edged sword for atherosclerosis.

Objective

The purpose of this study was to evaluate the relationship between HDL-C levels and endothelial function in men.

Methods

This was a cross-sectional study. We evaluated flow-mediated vasodilation (FMD) and serum levels of HDL-C in 5842 men aged 18 to 92 years who were not receiving lipid-lowering therapy. All participants were divided into four groups by HDL-C level: low HDL-C (<40 mg/dL), moderate HDL-C (40–59 mg/dL), high HDL-C (60–79 md/dL), and extremely high HDL-C (≥80 mg/dL). We were not able to evaluate the amount of alcohol intake because there was limited information on the amount of alcohol drinking in our database.

Results

FMD values were significantly smaller in the low group and the extremely high group than in the high group (P = .001 and P = .016, respectively). There was no significant difference in FMD between the low group and the extremely high group. Multiple logistic regression analysis revealed that extremely high HDL-C, but not low HDL-C, was independently associated with the lowest quartile of FMD (odds ratio: 1.39, 95% confidence interval: 1.09–1.77; P = .009).

Conclusions

An extremely high level of HDL-C in men (8.1% of this population) was associated with a significant reduction in FMD.

中文翻译：

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极高水平的高密度脂蛋白胆固醇与男性内皮功能障碍的关系。

背景

尚不清楚高水平的高密度脂蛋白胆固醇（HDL-C）是否与较低的动脉粥样硬化风险相关。HDL-C很可能是动脉粥样硬化的双刃剑。

客观的

这项研究的目的是评估男性HDL-C水平与内皮功能之间的关系。

方法

这是一项横断面研究。我们评估了5842名未接受降脂治疗的年龄在5842岁的男性中的血流介导的血管舒张（FMD）和血清HDL-C水平。所有参与者按HDL-C水平分为四组：低HDL-C（<40 mg / dL），中度HDL-C（40–59 mg / dL），高HDL-C（60–79 md / dL） ，以及极高的HDL-C（≥80mg / dL）。由于数据库中有关饮酒量的信息有限，因此我们无法评估饮酒量。

结果

在低组和极高组中，FMD值显着小于高组（分别为P  = .001和P  = .016）。低位组和极高位组之间的口蹄疫发生率无显着差异。多元logistic回归分析显示，HDL-C极高而不是HDL-C极低与FMD的最低四分位数独立相关（优势比：1.39，95％置信区间：1.09–1.77；P  = 0.009 ）。

结论

男性中高水平的HDL-C水平（占该人群的8.1％）与FMD的显着降低有关。