Inflammatory bowel disease (IBD) is characterized by uncontrolled inflammation in the gastrointestinal tract. The underlying pathobiology of IBD includes an increase in infiltrating gut‐homing lymphocytes. Although lymphocyte homing is typically a tightly regulated and stepwise process involving multiple integrins and adhesion molecules expressed on endothelial cells, the distinct roles of integrin‐expressing immune cells is not fully understood in the pathology of IBD. In this review, we detail the involvement of integrins expressed on specific lymphocyte subsets in the pathogenesis of IBD and discuss the current status of approved and investigational integrin‐targeted therapies.

中文翻译：

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整联蛋白在炎症性肠病发病机理中的作用：经过批准的和研究性的抗整联蛋白疗法。

炎症性肠病（IBD）的特征是胃肠道炎症不受控制。IBD的基础病理生物学包括浸润的肠归巢淋巴细胞的增加。尽管淋巴细胞归巢通常是一个严格调控的逐步过程，涉及在内皮细胞上表达的多种整合素和粘附分子，但在IBD的病理学中尚不能完全理解表达整联蛋白的免疫细胞的独特作用。在这篇综述中，我们详细介绍了在特定的淋巴细胞亚群上表达的整合素在IBD发病机理中的作用，并讨论了已批准和研究的以整合素为靶标的治疗方法的现状。