To gain unfettered insight into one of the scourges of our aging societies, Mathys and colleagues in Nature (Mathys et al., 2019) illuminate the brain transcriptome of Alzheimer’s disease at single-cell resolution. Their findings implicate oligodendrocytes, a cell type largely neglected in Alzheimer’s disease research, and sex in the disease in intriguing ways.

中文翻译：

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一个80,000片的阿尔茨海默氏病拼图

为了不受限制地洞察我们衰老社会的祸害之一，马西斯（Mathys）和自然界的同事们（Mathys等人，2019）以单细胞分辨率阐明了阿尔茨海默氏病的大脑转录组。他们的发现暗示了少突胶质细胞（一种在阿尔茨海默氏病研究中被广泛忽视的细胞类型）以及这种疾病的性别引人入胜。