BACKGROUND Several studies have found that the microbiota of psoriatic lesions is different from that of healthy skin. OBJECTIVE To characterize the microbiota of lesional and unaffected skin in patients with psoriasis and controls and investigate the correlation between cutaneous microbiota and clinical features of psoriasis. METHODS Using quantitative polymerase chain reaction and 16S rRNA sequencing, we assayed the profiles of cutaneous microbiota in controls, unaffected skin, and psoriatic lesions. We also investigated the correlation of psoriasis-associated taxa with clinical characteristics. RESULTS High bacterial load was identified in the psoriatic lesions compared with unaffected skin and controls. There was an imbalance between Cutibacterium (also known as Propionibacterium) and Corynebacterium in psoriatic skin. Lesions showed a higher proportion of Corynebacterium and a lower proportion of Cutibacterium compared with unaffected skin and controls. Corynebacterium was correlated with the severity of local lesions, whereas Cutibacterium showed correlation with the abnormity of skin capacitance. LIMITATIONS We did not conduct a longitudinal study. CONCLUSIONS Psoriatic lesions are characterized by higher bacterial load and imbalance between Cutibacterium and Corynebacterium.

中文翻译：

---

银屑病性病变的特征在于较高的细菌负荷以及角质杆菌和棒状杆菌之间的不平衡。

背景技术几项研究发现银屑病皮损的微生物群与健康皮肤的微生物群不同。目的对牛皮癣患者和对照组的病灶和未患病皮肤的微生物菌群进行鉴定，并研究皮肤微生物菌群与牛皮癣临床特征之间的相关性。方法使用定量聚合酶链反应和16S rRNA测序，我们分析了对照，未受影响的皮肤和牛皮癣病灶中皮肤微生物群的分布。我们还调查了牛皮癣相关的分类单元与临床特征的相关性。结果与未受影响的皮肤和对照组相比，在银屑病皮损中发现了高细菌载量。银屑病皮肤中的角质层杆菌（也称为丙酸杆菌）和棒状杆菌之间不平衡。与未受影响的皮肤和对照组相比，病变显示棒状杆菌的比例更高，而角质层细菌的比例更低。棒状杆菌与局部病变的严重程度相关，而角叉杆菌与皮肤电容异常相关。局限性我们没有进行纵向研究。结论银屑病皮损的特点是细菌负荷较高，并且皮肤杆菌和棒状杆菌之间不平衡。