Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids which possess a wide range of pharmacological activities. Recent evidence indicates that B and BA have several properties useful for the treatment of metabolic disorders, infectious diseases, cardiovascular disorders, and neurological disorders. In the current review, we discuss B and BA structures and derivatives and then comprehensively explain their pharmacological effects in relation to various diseases. We also explain antiviral, antibacterial and anti-cancer effects of B and BA. Finally, we discuss the delivery methods, in which these compounds most effectively target different systems.

Betulin（B）和Betulinic acid（BA）是天然的五环戊烷结构的三萜类化合物，具有广泛的药理活性。最近的证据表明，B和BA具有用于治疗代谢紊乱，传染病，心血管疾病和神经系统疾病的几种特性。在当前的审查中，我们讨论B和BA结构和衍生物，然后全面解释其与各种疾病有关的药理作用。我们还解释了B和BA的抗病毒，抗菌和抗癌作用。最后，我们讨论了这些化合物最有效地针对不同系统的递送方法。