Mitochondrial dysfunction is now recognized as a contributing factor to the early pathology of multiple human conditions including neurodegenerative diseases. Mitochondria are signaling organelles with a multitude of functions ranging from energy production to a regulation of cellular metabolism, energy homeostasis, stress response, and cell fate. The success of these complex processes critically depends on the fidelity of mitochondrial dynamics that include the ability of mitochondria to change shape and location in the cell, which is essential for the maintenance of proper function and quality control, particularly in polarized cells such as neurons. This review highlights several aspects of alterations in mitochondrial dynamics in Alzheimer's disease, which may contribute to the etiology of this debilitating condition. We also discuss therapeutic strategies to improve mitochondrial dynamics and function that may provide an alternative approach to failed amyloid-directed interventions.

中文翻译：

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阿尔茨海默氏病的线粒体动力学和转运。

线粒体功能障碍现已被认为是导致多种人类疾病（包括神经退行性疾病）的早期病理的因素。线粒体是具有多种功能的信号细胞器，范围从能量产生到细胞代谢，能量稳态，应激反应和细胞命运的调节。这些复杂过程的成功关键取决于线粒体动力学的保真度，其中包括线粒体改变细胞中形状和位置的能力，这对于维持适当的功能和质量控制至关重要，尤其是在极化细胞（如神经元）中。这篇综述强调了阿尔茨海默氏病线粒体动力学改变的几个方面，这可能是导致这种衰弱性疾病的病因。