The dynamic and fluid nature of mitochondria allows for modifications in mitochondrial shape, connectivity and cristae architecture. The precise balance of mitochondrial dynamics is among the most critical features in the control of mitochondrial function. In the past few years, mitochondrial shape has emerged as a key regulatory factor in the determination of the bioenergetic capacity of cells. This is mostly due to the recent discoveries linking changes in cristae organization with supercomplex assembly of the electron transport chain (ETC), also defined as the formation of respirosomes. Here we will review the most current advances demonstrating the impact of mitochondrial dynamics and cristae shape on oxidative metabolism, respiratory efficiency, and redox state. Furthermore, we will discuss the implications of mitochondrial dynamics and supercomplex assembly under physiological and pathological conditions.

中文翻译：

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将线粒体动力学、嵴重塑和超复合物形成联系起来：线粒体结构如何调节生物能量学

线粒体的动态和流动性质允许改变线粒体形状、连接性和嵴结构。线粒体动力学的精确平衡是控制线粒体功能的最关键特征之一。在过去几年中，线粒体形状已成为决定细胞生物能量能力的关键调节因素。这主要是由于最近发现将嵴组织的变化与电子传递链 (ETC) 的超复合组装联系起来，也被定义为呼吸体的形成。在这里，我们将回顾最新进展，证明线粒体动力学和嵴形状对氧化代谢、呼吸效率和氧化还原状态的影响。此外，