Cilia are microtubule-based organelles located at the cell surface of many eukaryotic cell types. Cilia control different cellular functions ranging from motility (for motile cilia) to signal transduction pathways (for primary cilia). A variety of signaling pathways are coordinated by this organelle during development, cell migration and cell differentiation. Interestingly, aberrant ciliogenesis or altered cilium signaling has been associated with human diseases, notably in cancer. Disruption of cilia through mutation of genes encoding cilia proteins has been also linked to multiple human disorders referred as ciliopathies. Recent studies highlight the interplay between cilia and proteostasis. Here we review findings regarding the crosstalk between cilia and two proteolytic systems, the ubiquitin proteasome system and the autophagy-lysosomal system and discuss the potential implications in human disease including ciliopathies.

中文翻译：

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原发性纤毛，泛素-蛋白酶体系统与自噬之间的相互作用。

纤毛是位于许多真核细胞类型的细胞表面的基于微管的细胞器。纤毛控制着不同的细胞功能，从运动性（对于活动性纤毛）到信号转导途径（对于原发性纤毛）。在发育，细胞迁移和细胞分化过程中，该细胞器可协调多种信号传导途径。有趣的是，异常纤毛发生或纤毛信号改变已与人类疾病相关，特别是在癌症中。通过编码纤毛蛋白的基因突变而破坏纤毛也与多种人类疾病相关，这些疾病被称为纤毛病。最近的研究强调纤毛和蛋白稳态之间的相互作用。在这里，我们回顾了有关纤毛和两个蛋白水解系统之间串扰的发现，