Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung malignances and median survival is only 6–12 months.¹ It is well accepted that the development of all malignancies including metastasis and their low sensitivity to antitumor treatments could be attributed to the cancer stem cells (CSCs), which have the ability to initiate and colonize at distant secondary tissue sites.^2–7 Among the various molecular signaling pathways in cells, Notch, WNT, and hedgehog are the three main pathways that are believed to be related to cancer stemness.^2,4–7 Understanding the key signaling pathways of lung CSCs is of pivotal and clinical importance for new drug discovery and development.²

中文翻译：

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EGFR-AS1/HIF2A 调控 FOXP3 表达影响吸烟相关非小细胞肺癌的癌症干性

肺癌是全球癌症相关死亡的主要原因。非小细胞肺癌 (NSCLC) 约占肺部恶性肿瘤的 85%，中位生存期仅为 6-12 个月。¹人们普遍认为，包括转移在内的所有恶性肿瘤的发展及其对抗肿瘤治疗的低敏感性可归因于癌症干细胞 (CSC)，其具有在远处继发组织部位启动和定植的能力。^2-7在细胞中的各种分子信号通路中，Notch、WNT 和hedgehog 是被认为与癌症干性相关的三个主要通路。^2,4-7了解肺 CSC 的关键信号通路对于新药的发现和开发具有关键的临床意义。²