Tissue homeostasis depends on a balance of synthesis and degradation of constituent proteins, with turnover of a given protein potentially regulated by its use. Extracellular matrix (ECM) is predominantly composed of fibrillar collagens that exhibit tension-sensitive degradation, which we review here at different levels of hierarchy. Past experiments and recent proteomics measurements together suggest that mechanical strain stabilizes collagen against enzymatic degradation at the scale of tissues and fibrils whereas isolated collagen molecules exhibit a biphasic behavior that depends on load magnitude. Within a Michaelis-Menten framework, collagenases at constant concentration effectively exhibit a low activity on substrate fibrils when the fibrils are strained by tension. Mechanisms of such mechanosensitive regulation are surveyed together with relevant interactions of collagen fibrils with cells.

中文翻译：

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原纤维中的张力抑制了它们的酶降解-一种“使用它或失去它”的分子机制。

组织动态平衡取决于组成蛋白的合成和降解之间的平衡，给定蛋白的转换可能受其使用的调节。细胞外基质（ECM）主要由表现出张力敏感降解的纤维状胶原组成，我们在此以不同层次的层次对其进行回顾。过去的实验和最近的蛋白质组学测量结果共同表明，机械应变可稳定胶原蛋白，使其在组织和原纤维范围内不会发生酶促降解，而分离的胶原蛋白分子则表现出取决于负荷量的双相行为。在Michaelis-Menten框架内，当原纤维受到张力拉紧时，恒定浓度的胶原酶对底物原纤维有效地表现出低活性。