FLT3 overexpression is a recurrent event in various acute leukaemia subtypes. This transcriptional deregulation is important to define the prognostic risk for many patients. Of note, the molecular mechanisms leading to this gene upregulation are unknown for a substantial number of cases. In this Mini-Review, we highlight the role of FLT3 overexpression in acute leukaemia and discuss emerging mechanisms accounting for this upregulation. The benefits of using targeted therapy are also addressed in the overexpression context, posing other therapeutic possibilities based on state-of-the-art knowledge that could be considered for future research.

中文翻译：

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FLT3在急性白血病中的过度表达：寻找分子机制的新见解

FLT3过表达是各种急性白血病亚型的复发事件。这种转录失调对于确定许多患者的预后风险很重要。值得注意的是，导致这种基因上调的分子机制在很多情况下是未知的。在本小型审查中，我们重点介绍了FLT3过表达在急性白血病中的作用，并讨论了导致这种上调的新兴机制。在过度表达的背景下，也可以解决使用靶向疗法的好处，并基于可以被未来研究考虑的最新知识，带来其他治疗可能性。