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Polyvalent Nanoobjects for Precision Diagnostics.
Annual Review of Analytical Chemistry ( IF 5.9 ) Pub Date : 2019-06-12 , DOI: 10.1146/annurev-anchem-061318-114938
David T Omstead 1 , Jenna Sjoerdsma 1 , Basar Bilgicer 1, 2, 3, 4
Affiliation  

As our ability to synthesize and modify nanoobjects has improved, efforts to explore nanotechnology for diagnostic purposes have gained momentum. The variety of nanoobjects, especially those with polyvalent properties, displays a wide range of practical and unique properties well suited for applications in various diagnostics. This review briefly covers the broad scope of multivalent nanoobjects and their use in diagnostics, ranging from ex vivo assays and biosensors to in vivo imaging. The nanoobjects discussed here include silica nanoparticles, gold nanoparticles, quantum dots, carbon dots, fullerenes, polymers, dendrimers, liposomes, nanowires, and nanotubes. In this review, we describe recent reports of novel applications of these various nanoobjects, particularly as polyvalent entities designed for diagnostics.

中文翻译:

用于精密诊断的多价纳米物体。

随着我们合成和修饰纳米物体的能力提高,探索用于诊断目的的纳米技术的努力得到了发展。各种各样的纳米物体,特别是具有多价性质的物体,显示出广泛的实用且独特的性质,非常适合在各种诊断中的应用。这篇综述简要涵盖了多价纳米物体的广泛范围及其在诊断中的用途,从离体测定和生物传感器到体内成像。这里讨论的纳米物体包括二氧化硅纳米粒子,金纳米粒子,量子点,碳点,富勒烯,聚合物,树枝状聚合物,脂质体,纳米线和纳米管。在这篇综述中,我们描述了这些纳米物体的新颖应用的最新报道,特别是作为设计用于诊断的多价实体。
更新日期:2020-04-21
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