Catatonia is a nosologically unspecific syndrome, which subsumes a plethora of mostly complex affective, motor, and behavioral phenomena. Although catatonia frequently occurs in schizophrenia spectrum disorders (SSD), specific patterns of abnormal brain structure and function underlying catatonia are unclear at present. Here, we used a multivariate data fusion technique for multimodal magnetic resonance imaging (MRI) data to investigate patterns of aberrant intrinsic neural activity (INA) and gray matter volume (GMV) in SSD patients with and without catatonia. Resting-state functional MRI and structural MRI data were collected from 87 right-handed SSD patients. Catatonic symptoms were examined on the Northoff Catatonia Rating Scale (NCRS). A multivariate analysis approach was used to examine co-altered patterns of INA and GMV. Following a categorical approach, we found predominantly frontothalamic and corticostriatal abnormalities in SSD patients with catatonia (NCRS total score ≥ 3; n = 24) when compared to SSD patients without catatonia (NCRS total score = 0; n = 22) matched for age, gender, education, and medication. Corticostriatal network was associated with NCRS affective scores. Following a dimensional approach, 33 SSD patients with catatonia according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision were identified. NCRS behavioral scores were associated with a joint structural and functional system that predominantly included cerebellar and prefrontal/cortical motor regions. NCRS affective scores were associated with frontoparietal INA. This study provides novel neuromechanistic insights into catatonia in SSD suggesting co-altered structure/function-interactions in neural systems subserving coordinated visuospatial functions and motor behavior.

中文翻译：

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多峰磁共振成像数据融合揭示了卡塔尼亚地区大脑结构和功能异常的独特模式。

卡塔顿尼亚是一种非病态的非特异性综合症，其中包含许多复杂的情感，运动和行为现象。尽管精神分裂症谱系障碍（SSD）中经常发生卡塔顿，但目前尚不清楚卡塔顿潜在的大脑结构和功能异常的具体模式。在这里，我们对多模式磁共振成像（MRI）数据使用了多变量数据融合技术，以研究伴有和不伴有卡塔尼亚症的SSD患者异常固有神经活动（INA）和灰质体积（GMV）的模式。静息状态功能性MRI和结构性MRI数据来自87位右撇子SSD患者。用Northoff Catatonia评定量表（NCRS）检查了紧张症状。多变量分析方法用于检查INA和GMV的共同变更模式。按照分类方法，我们发现，与年龄相匹配的未卡塔尼亚的SSD患者（NCRS总得分≥3； n = 24）相比，患有卡塔尼亚的SSD患者主要是前丘脑和皮质口畸形（NCRS总得分= 0； n = 22）。性别，教育程度和药物治疗。皮层神经网络与NCRS情感评分相关。按照尺寸方法，根据《精神障碍诊断和统计手册》第四版，文本修订版，确定了33名患有精神紧张症的SSD患者。NCRS行为评分与主要包括小脑和前额叶/皮层运动区域的关节结构和功能系统有关。NCRS情感评分与额顶INA相关。