There is increasing interest in helminth parasite modulation of the immune system, both from the fundamental perspective of the “arms race” between host and parasite, and equally importantly, to understand if parasites offer new pathways to abate and control untoward immune responses in humans. This article reviews the epidemiological and experimental evidence for parasite down‐regulation of host immunity and immunopathology, in allergy and other immune disorders, and recent progress towards defining the mechanisms and molecular mediators which parasites exploit in order to modulate their host. Among these are novel products that interfere with epithelial cell alarmins, dendritic cell activation, macrophage function and T‐cell responsiveness through the promotion of an immunoregulatory environment. These modulatory effects assist parasites to establish and survive, while dampening immune reactivity to allergens, autoantigens and microbiome determinants.

中文翻译：

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蠕虫寄生虫对免疫和过敏的调节

从宿主和寄生虫之间“军备竞赛”的基本角度来看，人们对蠕虫寄生虫对免疫系统的调节越来越感兴趣，同样重要的是，要了解寄生虫是否提供了新的途径来减轻和控制人类的不良免疫反应。本文回顾了寄生虫在过敏和其他免疫疾病中下调宿主免疫和免疫病理学的流行病学和实验证据，以及在确定寄生虫利用以调节宿主的机制和分子介质方面的最新进展。其中包括通过促进免疫调节环境干扰上皮细胞警报素、树突细胞活化、巨噬细胞功能和 T 细胞反应性的新产品。