The roles of structural dynamics in the cellular functions of RNAs.,Nature Reviews Molecular Cell Biology

当前位置： X-MOL 学术 › Nat. Rev. Mol. Cell Biol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The roles of structural dynamics in the cellular functions of RNAs.
Nature Reviews Molecular Cell Biology ( IF 81.3 ) Pub Date : 2019-08-01 , DOI: 10.1038/s41580-019-0136-0
Laura R Ganser ₁ , Megan L Kelly ₁ , Daniel Herschlag _{2,

3,

4} , Hashim M Al-Hashimi _{1,

5}

Affiliation

RNAs fold into 3D structures that range from simple helical elements to complex tertiary structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory RNAs depend on how their 3D structure changes in response to a diverse array of cellular conditions. In this Review, we examine how the structural characterization of RNA as dynamic ensembles of conformations, which form with different probabilities and at different timescales, is improving our understanding of RNA function in cells. We discuss the mechanisms of gene regulation by microRNAs, riboswitches, ribozymes, post-transcriptional RNA modifications and RNA-binding proteins, and how the cellular environment and processes such as liquid-liquid phase separation may affect RNA folding and activity. The emerging RNA-ensemble-function paradigm is changing our perspective and understanding of RNA regulation, from in vitro to in vivo and from descriptive to predictive.

中文翻译：

结构动力学在RNA的细胞功能中的作用。

RNA折叠成3D结构，范围从简单的螺旋元素到复杂的三级结构和四级核糖核蛋白装配体。许多调节性RNA的功能取决于其3D结构如何响应各种各样的细胞条件而变化。在这篇综述中，我们研究了作为动态构象的RNA的结构特征，这些构象以不同的概率和在不同的时间尺度上形成，如何增进了我们对细胞中RNA功能的理解。我们讨论了通过microRNA，核糖开关，核酶，转录后RNA修饰和RNA结合蛋白进行基因调控的机制，以及细胞环境和过程（例如液-液相分离）如何影响RNA折叠和活性。

更新日期：2019-11-18

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11