Integrins as biomechanical sensors of the microenvironment.,Nature Reviews Molecular Cell Biology

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Integrins as biomechanical sensors of the microenvironment.
Nature Reviews Molecular Cell Biology ( IF 81.3 ) Pub Date : 2019-08-01 , DOI: 10.1038/s41580-019-0134-2
Jenny Z Kechagia ₁ , Johanna Ivaska _{2,

3} , Pere Roca-Cusachs _{1,

4}

Affiliation

Integrins, and integrin-mediated adhesions, have long been recognized to provide the main molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional hubs transmitting signals between cells and their environment. Recent evidence has shown that their combined biochemical and mechanical properties also allow integrins to sense, respond to and interact with ECM of differing properties with exquisite specificity. Here, we review this work first by providing an overview of how integrin function is regulated from both a biochemical and a mechanical perspective, affecting integrin cell-surface availability, binding properties, activation or clustering. Then, we address how this biomechanical regulation allows integrins to respond to different ECM physicochemical properties and signals, such as rigidity, composition and spatial distribution. Finally, we discuss the importance of this sensing for major cell functions by taking cell migration and cancer as examples.

中文翻译：

整合素作为微环境的生物力学传感器。

长期以来，人们一直认为整联蛋白和整联蛋白介导的粘附作用可提供将细胞连接至细胞外基质（ECM）的主要分子连接，并充当双向枢纽，在细胞与周围环境之间传递信号。最近的证据表明，它们综合的生化和机械特性也使整联蛋白能够以出色的特异性感应，响应不同特性的ECM并与之相互作用。在这里，我们首先通过从生物化学和机械角度综述整合素功能的调控方式，从而影响整合素细胞表面的可用性，结合特性，活化或聚类，来综述这项工作。然后，我们讨论这种生物力学调节如何使整联蛋白响应不同的ECM物理化学特性和信号，例如硬度，组成和空间分布。最后，我们以细胞迁移和癌症为例，讨论这种感知对主要细胞功能的重要性。

更新日期：2019-11-18

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