Miniaturization of electronic components and advances in flexible and stretchable materials have stimulated the development of wearable health care systems that can reflect and monitor personal health status by health care professionals. New skin-mountable devices that offer seamless contact onto the human skin, even under large deformations by natural motions of the wearer, provide a route for both high-fidelity monitoring and patient-controlled therapy. This article provides an overview of several important aspects of skin-mountable devices and their applications in many medical settings and clinical practices. We comprehensively describe various transdermal sensors and therapeutic systems that are capable of detecting physical, electrophysiological, and electrochemical responses and/or providing electrical and thermal therapies and drug delivery services, and we discuss the current challenges, opportunities, and future perspectives in the field. Finally, we present ways to protect the embedded electronic components of skin-mountable devices from the environment by use of mechanically soft packaging materials.

中文翻译：

---

皮肤固定式生物传感器和治疗学：综述。

电子组件的小型化以及柔性和可拉伸材料的发展刺激了可穿戴医疗系统的发展，该系统可以反映和监控医疗专业人员的个人健康状况。即使在穿戴者自然运动造成的大变形下，也可以提供与人体皮肤无缝接触的新型可皮肤安装设备，为高保真监测和患者控制的治疗提供了一条途径。本文概述了可皮肤贴装设备的几个重要方面及其在许多医疗环境和临床实践中的应用。我们全面介绍了各种能够检测物理，电生理，电化学响应和/或提供电热疗法和药物递送服务，我们将讨论该领域当前的挑战，机遇和未来前景。最后，我们提出了通过使用机械软包装材料来保护可皮肤贴装设备的嵌入式电子组件免受环境影响的方法。