In recent years, a diverse set of mechanisms have been developed that allow DNA strands with specific sequences to sense information in their environment and to control material assembly, disassembly, and reconfiguration. These sequences could serve as the inputs and outputs for DNA computing circuits, enabling DNA circuits to act as chemical information processors to program complex behavior in chemical and material systems. This review describes processes that can be sensed and controlled within such a paradigm. Specifically, there are interfaces that can release strands of DNA in response to chemical signals, wavelengths of light, pH, or electrical signals, as well as DNA strands that can direct the self-assembly and dynamic reconfiguration of DNA nanostructures, regulate particle assemblies, control encapsulation, and manipulate materials including DNA crystals, hydrogels, and vesicles. These interfaces have the potential to enable chemical circuits to exert algorithmic control over responsive materials, which may ultimately lead to the development of materials that grow, heal, and interact dynamically with their environments.

中文翻译：

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使用DNA电路在分子规模上控制物质。

近年来，已经开发了多种机制，这些机制允许具有特定序列的DNA链在其环境中感知信息并控制材料的组装，拆卸和重新配置。这些序列可以用作DNA计算电路的输入和输出，从而使DNA电路可以充当化学信息处理器，以对化学和材料系统中的复杂行为进行编程。这篇评论描述了可以在这种范式中感知和控制的过程。具体来说，有些界面可以根据化学信号，光的波长，pH或电信号释放DNA链，还可以指导DNA纳米结构的自组装和动态重配置，调节颗粒组装，控制封装 并操纵包括DNA晶体，水凝胶和囊泡在内的材料。这些接口具有使化学电路能够对响应材料进行算法控制的潜力，这最终可能导致开发出能够生长，愈合并与其环境动态交互的材料。