BackgroundCardiac amyloidosis is a substantially underdiagnosed disease, and contemporary estimates of the epidemiology of amyloidosis are lacking. This study aims to determine the incidence and prevalence of cardiac amyloidosis among Medicare beneficiaries from 2000 to 2012.Methods and ResultsMedicare beneficiaries were counted in the prevalence cohort in each year they had (1) ≥1 principal or secondary International Classification of Diseases, Ninth Revision code for amyloidosis and (2) ≥1 principal or secondary International Classification of Diseases, Ninth Revision code for heart failure or cardiomyopathy within 2 years after the systemic amyloidosis code. A beneficiary was counted in the incidence cohort only during the first year in which they met criteria. Primary outcomes included the prevalence and incidence of hospitalizations for cardiac amyloidosis. There were 4746 incident cases of cardiac amyloidosis in 2012 and 15 737 prevalent cases in 2012. There was also a significant increase in the prevalence rate (8 to 17 per 100 000 person-years) and incidence rate (18 to 55 per 100 000 person-years) from 2000 to 2012, most notable after 2006. Incidence and prevalence increased substantially more among men, the elderly, and in blacks.ConclusionsThe incidence and prevalence rates of cardiac amyloidosis are higher than previously thought. The incidence and prevalence rates of cardiac amyloidosis among hospitalized patients have increased since 2000, particularly among specific patient subgroups and after 2006, suggesting improved amyloidosis awareness and higher diagnostic rates with noninvasive imaging. In light of these trends, cardiac amyloidosis should be considered during the initial work up of patients ≥65 years old hospitalized with heart failure.

中文翻译：

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美国收费医疗保险受益人中与心脏淀粉样变性相关的心力衰竭住院的流行病学。

背景技术心脏淀粉样变性病是一种被充分诊断的疾病，目前缺乏对淀粉样变性病流行病学的现代估计。这项研究的目的是确定的发病率从2000年的医疗保险受益人之间的心脏淀粉样变性的患病率2012.Methods和ResultsMedicare受益者患病人群进行计数，每年他们有（1）≥1主要或次要国际疾病分类，第九版淀粉样变性病代码和（2）≥1主要或次要国际疾病分类，第九版系统性淀粉样变性病代码后2年内的心力衰竭或心肌病代码。仅在符合条件的第一年才将受益人计入发病队列。主要结果包括心脏淀粉样变性病的患病率和住院率。2012年，发生心脏淀粉样变性的事件为4746例，2012年为15737例。患病率（每10万人年8至17人）和发病率（每10万人18至55人）也有显着增加。 （2000年至2012年），最明显的是2006年以后。男性，老年人和黑人的发病率和患病率显着增加。结论心脏淀粉样变性病的发病率和患病率高于以前的预期。自2000年以来，住院患者中心脏淀粉样变性病的发生率和患病率有所增加，特别是在特定的患者亚组中以及2006年之后，这表明淀粉样变性病的认识有所提高，无创成像技术的诊断率更高。根据这些趋势，在≥65岁住院的心力衰竭患者的初次检查期间应考虑心脏淀粉样变性。