The formation of tumors is modulated by multiple soluble and immobilized molecular factors including proteases, growth factors, extracellular matrix components, etc. Increasing evidence has shown that tumors can mimic embryonic development. Therefore, multiple molecular cytokines that affect embryonic development have been investigated in cancer progression. The SLIT/ROBO pathway is particularly involved in embryonic development.¹ Gara et al.² reviewed the roles of the SLIT/ROBO pathway in different types of cancer, molecular crosstalk, and the modulation of oncogenic signaling pathways. Huang et al.³ summarized the SLIT/ROBO pathway and its biological significance in gastrointestinal cancers. Recent studies showed that the SLIT/ROBO pathway can produce both beneficial and detrimental effects in the growth of malignant cells. It seems that SLIT/ROBO play contradictory roles in tumorigenesis. Therefore, in this brief review, the tumor promotion and tumor suppression roles of the SLIT/ROBO pathway and its biological significance in cancer will be summarized.

中文翻译：

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在肿瘤进展中靶向SLIT / ROBO途径：分子机制和治疗观点

肿瘤的形成受到多种可溶性和固定化分子因子（包括蛋白酶，生长因子，细胞外基质成分等）的调节。越来越多的证据表明，肿瘤可以模拟胚胎发育。因此，已经在癌症进展中研究了影响胚胎发育的多种分子细胞因子。SLIT / ROBO途径特别参与胚胎发育。¹ Gara等。²综述了SLIT / ROBO途径在不同类型的癌症，分子串扰和致癌信号途径调节中的作用。黄等。³总结了SLIT / ROBO途径及其在胃肠道癌症中的生物学意义。最近的研究表明，SLIT / ROBO途径可以在恶性细胞的生长中产生有益和有害的作用。看起来SLIT / ROBO在肿瘤发生中起着矛盾的作用。因此，在这篇简短的综述中，将总结SLIT / ROBO途径在肿瘤中的促进和抑制作用及其在癌症中的生物学意义。