Osteosarcoma (OSA) is the most common primary malignant tumor of the bones. Of note, OSA is the sixth most-frequent pediatric cancer and represents the second most common cause of cancer-related death in this age group; a second peak is observed in adults after the sixth decade of life.^1,2 Currently, primary OSA is classified into low- (Grade I) and high-grade subtypes (Grade II and III in the presence of metastasis), high-grade OSA being the most prevalent and aggressive variant.³

中文翻译：

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将 CSPG4 鉴定为骨肉瘤转化组合方法的有希望的靶点

骨肉瘤（OSA）是最常见的原发性骨骼恶性肿瘤。值得注意的是，OSA 是第六大最常见的儿科癌症，是该年龄段癌症相关死亡的第二大常见原因；在 60 岁后的成年人中观察到第二个高峰。^1,2目前，原发性 OSA 分为低级别（I 级）和高级别亚型（存在转移的 II 级和 III 级），高级别 OSA 是最普遍和最具侵袭性的变体。³