PURPOSE This study examined whether short-term use of topical nonsteroidal anti-inflammatory drug (NSAID) or steroid therapy affected the efficacy of selective laser trabeculoplasty (SLT). DESIGN Double-masked, randomized, placebo-controlled, dual-center, multisurgeon trial. PARTICIPANTS Patients older than 18 years with intraocular pressure (IOP) of more than 18 mmHg for whom the clinician decided SLT was the appropriately indicated therapy were randomized to 1 of 3 groups in a ratio of 1:1:1 as follows: ketorolac 0.5%, prednisolone 1%, or saline tears. METHODS After SLT, patients randomized into each group were instructed to use an unmarked drop 4 times daily starting the day of SLT and continuing for 4 additional days. The Kruskal-Wallis test and Wilcoxon rank-sum test were used for continuous variables when comparing 2 or 3 treatment groups, respectively. The Fisher exact test was used for categorical variables. MAIN OUTCOME MEASURES The primary outcome of this study was IOP at 12 weeks. Secondary outcome measures included IOP at 1 and 6 weeks, patient-reported pain, and detectable anterior chamber inflammation. RESULTS Ninety-six eyes of 85 patients fit inclusion criteria and were enrolled between the 2 sites. The NSAID, steroid, and placebo groups were similar in baseline demographics and baseline IOP (mean, 23.3±3.9 mmHg; P = 0.57). There was no statistically significant difference in IOP decrease among groups at week 6. Both the NSAID and steroid groups showed a statistically significantly greater decrease in IOP at week 12 compared with the placebo group (mean, -6.2±3.1 mmHg, -5.2±2.7 mmHg, and -3±4.3 mmHg, respectively; P = 0.02 [analysis of variance] and P = 0.002 [t test] for NSAID vs. placebo groups; P = 0.02 for steroid vs. placebo groups). CONCLUSIONS Significantly better IOP reduction at 12 weeks was measured in eyes treated with steroid or NSAID drops after SLT. Short-term postoperative use of NSAID or steroid drops may improve IOP reduction after SLT. Longer-term follow-up studies are indicated.

中文翻译：

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SALT试验：激光小梁成形术后的类固醇：短期抗炎治疗对选择性激光小梁成形术功效的影响。

目的该研究检查了短期使用局部非甾体类抗炎药（NSAID）或类固醇疗法是否会影响选择性激光小梁成形术（SLT）的疗效。设计双盲，随机，安慰剂对照，双中心，多科医生试验。研究对象临床医师认为SLT是适当治疗的18岁以上眼内压（IOP）大于18 mmHg的患者，按以下比例按1：1：1比例随机分为3组中的1组：酮咯酸0.5％ ，泼尼松龙1％或盐水眼泪。方法SLT后，从SLT开始之日起，每天随机分为4组的患者被指示每天使用4次无标记滴剂，并继续使用4天。在比较2个或3个治疗组时，将Kruskal-Wallis检验和Wilcoxon秩和检验用于连续变量，分别。Fisher精确检验用于分类变量。主要观察指标这项研究的主要终点指标是12周时的眼压。次要结果指标包括1周和6周时的IOP，患者报告的疼痛以及可检测到的前房炎症。结果85例患者的96眼符合入选标准，并入选2个部位。NSAID，类固醇和安慰剂组在基线人口统计学和基线IOP方面相似（平均值为23.3±3.9 mmHg； P = 0.57）。各组在第6周的IOP降低没有统计学意义上的显着差异。与安慰剂组相比，NSAID组和类固醇组在第12周的IOP降低均具有统计学上显着的更大差异（平均值为-6.2±3.1 mmHg，-5.2±2.7 mmHg和-3±4.3 mmHg； P = 0.02 [方差分析]和P = 0。NSAID与安慰剂组的002 [t检验]；对于类固醇与安慰剂组，P = 0.02）。结论在SLT后用类固醇或NSAID滴眼液治疗的眼睛在12周时IOP降低明显更好。术后短期使用NSAID或类固醇滴剂可能会改善SLT后IOP的降低。需要进行长期的随访研究。