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Hybrid hydrogels for biomedical applications.
Current Opinion in Chemical Engineering ( IF 8.0 ) Pub Date : 2019-06-04 , DOI: 10.1016/j.coche.2019.02.010
Luisa L Palmese 1 , Raj Kumar Thapa 2 , Millicent O Sullivan 2 , Kristi L Kiick 1
Affiliation  

The use of hydrogels in biomedical applications dates back multiple decades, and the engineering potential of these materials continues to grow with discoveries in chemistry and biology. The approaches have led to increasing complex hydrogels that incorporate both synthetic and natural polymers and functional domains for tunable release kinetics, mediated cell response, and ultimately use in clinical and research applications in biomedical practice. This review focuses on recent advances in hybrid hydrogels that incorporate nano/microstructures, their synthesis, and applications in biomedical research. Examples discussed include the implementation of click reactions, photopatterning, and 3D printing for the facile production of these hybrid hydrogels, the use of biological molecules and motifs to promote a desired cellular outcome, and the tailoring of kinetic and transport behavior through hybrid-hydrogel engineering to achieve desired biomedical outcomes. Recent progress in the field has established promising approaches for the development of biologically relevant hybrid hydrogel materials with potential applications in drug discovery, drug/gene delivery, and regenerative medicine.

中文翻译:

用于生物医学的混合水凝胶。

水凝胶在生物医学应用中的使用可以追溯到几十年前,并且随着化学和生物学的发现,这些材料的工程潜力不断增长。这些方法导致越来越多的复杂水凝胶结合了合成和天然聚合物以及功能域,以实现可调的释放动力学,介导的细胞反应,并最终在生物医学实践的临床和研究应用中使用。这篇综述着重介绍了混合水凝胶的最新进展,这些水凝胶结合了纳米/微结构,其合成以及在生物医学研究中的应用。讨论的示例包括实现轻巧生产这些杂化水凝胶的点击反应,光图案化和3D打印的实现,生物分子和基序的使用以促进所需的细胞结果,以及通过混合水凝胶工程设计动力学和运输行为,以实现所需的生物医学成果。该领域的最新进展为开发生物学相关的杂化水凝胶材料建立了有前途的方法,这些材料在药物发现,药物/基因传递和再生医学中具有潜在的应用。
更新日期:2019-06-04
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