Ageing is the most important risk factor for the majority of human pathologies. We propose the concept that the advancement of the hallmarks of ageing is dictated by several distinct biological clocks that can be decelerated by the induction of autophagy. This ‘time dilation’ delays the time-dependent manifestation of multiple diseases. Kroemer and Lopez-Otín discuss how the induction of autophagy could slow down human ageing and thus also delay the onset of ageing-associated diseases, by decelerating biological clocks.

中文翻译：

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通过自噬减缓衰老和生物钟。

衰老是大多数人类疾病最重要的风险因素。我们提出这样一个概念，即衰老标志的进展是由几个不同的生物钟决定的，这些生物钟可以通过诱导自噬来减速。这种“时间膨胀”延迟了多种疾病的时间依赖性表现。Kroemer 和 Lopez-Otín 讨论了自噬的诱导如何通过减慢生物钟来减缓人类衰老，从而延缓衰老相关疾病的发作。