Assessment of vitamin D status and parathyroid hormone during a combined intervention for the treatment of childhood obesity.,Nutrition & Diabetes

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Assessment of vitamin D status and parathyroid hormone during a combined intervention for the treatment of childhood obesity.
Nutrition & Diabetes ( IF 4.6 ) Pub Date : 2019-06-04 , DOI: 10.1038/s41387-019-0083-z
Teodoro Durá-Travé _{1,

2,

3} , Fidel Gallinas-Victoriano ₂ , María Jesús Chueca-Guindulain _{2,

3} , Sara Berrade-Zubiri _{2,

3} , María Urretavizcaya-Martinez ₂ , Lotfi Ahmed-Mohamed ₂

Affiliation

BACKGROUND Obesity is associated with vitamin D deficiency. The aim of this work is to analyze the changes in vitamin D status and PTH levels in a group of children with obesity receiving combined intervention program in order to get BMI status reduction. METHODS Longitudinal study in 119 children with obesity, aged 9.1-13.9 years, included in a 1-year combined dietary-behavioral-physical activity intervention. Anthropometric measurements (weight, height, BMI and fat mass index) were registered every 3 months and blood testing (calcium, phosphorous, 25(OH)D and PTH) were collected at the beginning and after 12 months of follow-up. A control group was recruited (300 healthy children, aged 8.1-13.9 years). The criteria of the US Endocrine Society were used for the definition of hypovitaminosis D. RESULTS Vitamin D deficiency was significantly higher in obesity group (31.1 vs. 14%). There was negative correlation between 25(OH)D and fat mass index (r = -0.361, p = 0.001). Patients with BMI reduction throughout combined intervention were 52 (43.7%). There was a significant increase in the prevalence of hypovitaminosis D in patients without BMI reduction at the end of follow-up, but in those patients with BMI reduction there was no changes of vitamin D status. CONCLUSIONS Obesity increases the prevalence of suboptimal vitamin D status, and a BMI status reduction in children with obesity may be required to at least stabilize vitamin D status.

中文翻译：

在治疗儿童肥胖的联合干预期间评估维生素 D 状态和甲状旁腺激素。

背景技术肥胖与维生素D缺乏有关。这项工作的目的是分析一组接受联合干预计划的肥胖儿童的维生素 D 状态和 PTH 水平的变化，以降低 BMI 状态。方法对 119 名年龄 9.1-13.9 岁的肥胖儿童进行纵向研究，纳入为期 1 年的饮食-行为-体力活动综合干预措施。每 3 个月记录一次人体测量数据（体重、身高、BMI 和脂肪质量指数），并在随访开始时和 12 个月的随访后收集血液检测（钙、磷、25(OH)D 和 PTH）。招募对照组（300 名健康儿童，年龄 8.1-13.9 岁）。采用美国内分泌学会的标准来定义维生素 D 缺乏症。结果肥胖组维生素 D 缺乏率显着较高（31.1% vs. 14%）。 25(OH)D 与脂肪质量指数呈负相关（r = -0.361，p = 0.001）。在联合干预期间体重指数降低的患者有 52 名 (43.7%)。随访结束时BMI未降低的患者维生素D缺乏症的患病率显着增加，但BMI降低的患者维生素D状态没有变化。结论肥胖会增加维生素 D 状态不佳的发生率，并且可能需要降低肥胖儿童的 BMI 状态才能至少稳定维生素 D 状态。

更新日期：2019-06-04

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