Tattooing is a ubiquitous body modification involving the injection of ink and/or dye pigments into the dermis. Biosensors in the form of tattoos can be used to monitor metabolites in interstitial fluid. Here, minimally invasive, injectable dermal biosensors were developed for measuring pH, glucose, and albumin concentrations. The dermal pH sensor was based on methyl red, bromothymol blue, and phenolphthalein, which responded to a pH range from 5.0 to 9.0. The dermal glucose sensor consisted of glucose oxidase, 3,3′,5,5′‐tetramethylbenzidine, and peroxidase that detected concentrations up to 50.0 mmol L⁻¹. The dermal albumin sensor consisted of 3′,3′′,5′,5′′‐tetrachlorophenol‐3,4,5,6‐tetrabromosulfophthalein to measure concentrations up to 5.0 g L⁻¹. The sensors were multiplexed in ex vivo skin tissue and quantitative readouts were obtained using a smartphone camera. These sensors can be used to manage of acid–base homeostasis, diabetes, and liver failure in point‐of‐care settings.

中文翻译：

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用于比色代谢物检测的皮肤纹身生物传感器。

纹身是一种普遍存在的身体修饰，涉及将墨水和/或染料颜料注入到真皮中。纹身形式的生物传感器可用于监测组织液中的代谢产物。在这里，开发了微创，可注射的真皮生物传感器，用于测量pH，葡萄糖和白蛋白浓度。真皮pH传感器基于甲基红，溴百里酚蓝和酚酞，它们对pH范围从5.0到9.0响应。真皮葡萄糖传感器由葡萄糖氧化酶，3,3'，5,5'-四甲基联苯胺和过氧化物酶组成，其检测浓度最高为50.0 mmol L ^-1。皮肤白蛋白传感器由3'，3''，5'，5''-四氯苯酚-3,4,5,6-四溴磺磺酞组成，可测量高达5.0 g L ^-1的浓度。传感器在离体皮肤组织中多路复用，并使用智能手机相机获得定量读数。这些传感器可用于在现场护理环境中管理酸碱稳态，糖尿病和肝功能衰竭。