Neurons transcribe different genes in response to different extracellular stimuli, and these genes regulate neuronal plasticity. Thus, understanding how different stimuli regulate different stimulus-dependent gene modules would deepen our understanding of plasticity. To systematically dissect the coupling between stimulation and transcription, we propose creating a 'stimulation-transcription coupling map' that describes the transcription response to each possible extracellular stimulus. While we are currently far from having a complete map, recent genomic experiments have begun to facilitate its creation. Here, we describe the current state of the stimulation-transcription coupling map as well as the transcriptional regulation that enables this coupling.

中文翻译：

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神经元刺激-转录偶联图。

神经元响应于不同的细胞外刺激而转录不同的基因，并且这些基因调节神经元的可塑性。因此，了解不同的刺激如何调节不同的依赖于刺激的基因模块将加深我们对可塑性的理解。为了系统地分析刺激和转录之间的耦合，我们建议创建一个“刺激-转录偶联图”，该图描述对每种可能的细胞外刺激的转录反应。尽管我们目前还没有完整的地图，但最近的基因组实验已开始促进其创建。在这里，我们描述了刺激-转录偶联图谱的当前状态以及实现这种偶联的转录调控。