Overexpression of BMP1 reflects poor prognosis in clear cell renal cell carcinoma.,Cancer Gene Therapy

当前位置： X-MOL 学术 › Cancer Gene Ther. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Overexpression of BMP1 reflects poor prognosis in clear cell renal cell carcinoma.
Cancer Gene Therapy ( IF 4.8 ) Pub Date : 2019-06-03 , DOI: 10.1038/s41417-019-0107-9
Wen Xiao _{1,

2,

3,

4} , Xuegang Wang _{1,

2,

3,

4} , Tao Wang _{1,

2,

3,

4} , Jinchun Xing _{1,

2,

3,

4}

Affiliation

Clear cell renal cell carcinoma (ccRCC) is the highest mortality, invasion, and metastasis subtype of renal cell carcinoma. Bone morphogenetic protein (BMP) family has recently emerged as a group of cancer-related proteins in multiple pathogenesis of cancers. Currently, little is known about the prediction role of BMPs in ccRCC. Therefore, we screened The Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) database for ccRCC patients with complete clinical information and BMP family expression data. Multivariate analysis showed that high expression of BMP1 was associated with shorter overall survival (OS) (P = 0.001), and shorter disease-free survival (DFS) (P = 0.018). Gene set enrichment analysis (GSEA) showed BMP1 was associated with epithelial-mesenchymal transition (EMT), G2M checkpoint, angiogenesis, hypoxia pathway, and Kirsten rat sarcoma viral oncogene (KRAS) signaling. Knockdown BMP1 suppressed malignancy of ccRCC in vitro and in vivo. Our results indicated that high expressions of BMP1 were poor prognostic factors and gene therapy could be an effective treatment for ccRCC.

中文翻译：

BMP1的过表达反映了透明细胞肾细胞癌的不良预后。

透明细胞肾细胞癌（ccRCC）是肾细胞癌中死亡率、侵袭和转移率最高的亚型。骨形态发生蛋白 (BMP) 家族最近作为一组癌症相关蛋白出现在多种癌症发病机制中。目前，关于 BMP 在 ccRCC 中的预测作用知之甚少。因此，我们筛选了具有完整临床信息和 BMP 家族表达数据的 ccRCC 患者的癌症基因组图谱肾透明细胞癌 (TCGA-KIRC) 数据库。多变量分析表明，BMP1 的高表达与较短的总生存期 (OS) (P = 0.001) 和较短的无病生存期 (DFS) (P = 0.018) 相关。基因集富集分析 (GSEA) 显示 BMP1 与上皮间质转化 (EMT)、G2M 检查点、血管生成、缺氧途径、和 Kirsten 大鼠肉瘤病毒癌基因 (KRAS) 信号传导。敲低 BMP1 在体外和体内抑制 ccRCC 的恶性肿瘤。我们的研究结果表明，BMP1 的高表达是不良预后因素，基因治疗可能是 ccRCC 的有效治疗方法。

更新日期：2019-11-18

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11