We introduce a single channel neuro-stimulator consisting of a reflector-coupled microscale light emitting diode (µLED) with an integrated mm-sized wireless receiver (Rx) coil for free-floating, battery-free, untethered optogenetics neuromodulation. The system utilizes a two-coil inductive link to deliver instantaneous power at a low operating frequency (<100 MHz) for continuous optical stimulation with minimized invasiveness and tissue exposure to electromagnetic radiation. Coupling a microscale reflector to the µLED provides significant light intensity enhancement compared to a bare µLED. Our activated stimulators have an operational temperature increase of <1 °C, well below the safety limit of biomedical implants. In vivo experiment and histological analysis verify the efficacy of wireless optical stimulation in the primary visual cortex of rats, using c-Fos biomarker as a reporter of light-evoked neuronal activity.

我们介绍了一种单通道神经刺激器，它由一个反射器耦合的微型发光二极管 (μLED) 和一个集成的毫米尺寸无线接收器 (Rx) 线圈组成，用于自由浮动、无电池、不受限制的光遗传学神经调节。该系统利用双线圈电感链路以低工作频率 (<100 MHz) 提供瞬时功率，用于连续光刺激，同时最大限度地减少侵入性和组织暴露于电磁辐射。与裸 µLED 相比，将微型反射器耦合到 µLED 可显着增强光强度。我们激活的刺激器的工作温度升高 <1 °C，远低于生物医学植入物的安全极限。