BACKGROUND Perioperative fluid overload has been reported to increase complications after a variety of operative procedures. This study was conducted to investigate the incidence of fluid retention after pancreatic resection and its association with postoperative complications. METHODS Data from 1174 patients undergoing pancreatoduodenectomy between 2010 and 2016 were collected from the Swedish National Pancreatic and Periampullary Cancer Registry. Early postoperative fluid retention was defined as a weight gain ≥2 kg on postoperative day 1. Outcome measures were overall complications, as well as procedure-specific complications. RESULTS The weight change on postoperative day 1 ranged from -1 kg to +9 kg. A total of 782 patients (66.6%) were considered to have early fluid retention. Patients with fluid retention had significantly higher rates of total complications (p = 0.002), surgical complications (p = 0.001), pancreatic anastomotic leakage (p = 0.018) and wound infection (p = 0.023). Multivariable logistic regression confirmed early fluid retention as an independent risk factor for total complications (OR 1.46; p = 0.003), surgical complications (OR 1.49; p = 0.002), pancreatic anastomotic leakage (OR 1.48; p = 0.027) and wound infection (OR 1.84; p = 0.023). CONCLUSIONS Fluid retention is common after elective pancreatic resection, and its associated with an increased rate of postoperative complications.

中文翻译：

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术后早期积水是胰腺十二指肠切除术后并发症的有力预测指标。

背景技术据报道，围手术期液体超负荷会增加各种手术程序后的并发症。这项研究的目的是调查胰腺切除术后体液retention留的发生率及其与术后并发症的关系。方法从瑞典国家胰腺癌和壶腹癌登记处收集2010年至2016年间1174例接受胰十二指肠切除术的患者的数据。术后早期液体fluid留的定义为术后1天体重增加≥2kg。结果指标为总体并发症以及特定于手术的并发症。结果术后1天体重变化范围为-1 kg至+9 kg。总共782例患者（66.6％）被认为具有早期液体retention留。体液retention留的患者的总并发症（p = 0.002），手术并发症（p = 0.001），胰腺吻合口漏（p = 0.018）和伤口感染（p = 0.023）的发生率明显更高。多变量logistic回归证实早期积液是总并发症（OR 1.46; p = 0.003），手术并发症（OR 1.49; p = 0.002），胰腺吻合口漏（OR 1.48; p = 0.027）和伤口感染的独立危险因素（ OR 1.84； p = 0.023）。结论选择性胰腺切除术后体液retention留是常见的，并且与术后并发症发生率增加有关。多变量logistic回归证实早期积液是总并发症（OR 1.46; p = 0.003），手术并发症（OR 1.49; p = 0.002），胰腺吻合口漏（OR 1.48; p = 0.027）和伤口感染的独立危险因素（ OR 1.84； p = 0.023）。结论选择性胰腺切除术后体液retention留是常见的，并且与术后并发症发生率增加有关。多变量logistic回归确认早期积液是总并发症（OR 1.46; p = 0.003），手术并发症（OR 1.49; p = 0.002），胰腺吻合口漏（OR 1.48; p = 0.027）和伤口感染（ OR 1.84； p = 0.023）。结论选择性胰腺切除术后体液retention留是常见的，并且与术后并发症发生率增加有关。