Liquid biopsy in ovarian cancer: recent advances in circulating extracellular vesicle detection for early diagnosis and monitoring progression.,Theranostics

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Liquid biopsy in ovarian cancer: recent advances in circulating extracellular vesicle detection for early diagnosis and monitoring progression.
Theranostics ( IF 12.4 ) Pub Date : 2019-01-01 , DOI: 10.7150/thno.34692
Lei Chang ₁ , Jie Ni _{2,

3} , Ying Zhu _{2,

3} , Bairen Pang _{2,

3} , Peter Graham _{2,

3} , Hao Zhang _{4,

5} , Yong Li _{2,

3,

6}

Affiliation

The current biomarkers available in the clinic are not enough for early diagnosis or for monitoring disease progression of ovarian cancer. Liquid biopsy is a minimally invasive test and has the advantage of early diagnosis and real-time monitoring of treatment response. Although significant progress has been made in the usage of circulating tumor cells and cell-free DNA for ovarian cancer diagnosis, their potential for early detection or monitoring progression remains elusive. Extracellular vesicles (EVs) are a heterogeneous group of lipid membranous particles released from almost all cell types. EVs contain proteins, mRNA, DNA fragments, non-coding RNAs, and lipids and play a critical role in intercellular communication. Emerging evidence suggests that EVs have crucial roles in cancer development and metastasis, thus holding promise for liquid biopsy-based biomarker discovery for ovarian cancer diagnosis. In this review, we discuss the advantages of EV-based liquid biopsy, summarize the protein biomarkers identified from EVs in ovarian cancer, and highlight the utility of new technologies recently developed for EV detection with an emphasis on their use for diagnosing ovarian cancer, monitoring cancer progression, and developing personalized medicine.

中文翻译：

卵巢癌液体活检：循环细胞外囊泡检测的最新进展，用于早期诊断和监测进展。

临床上可用的生物标记物不足以早期诊断或监测卵巢癌的疾病进展。液体活检是一种微创检查，具有早期诊断和实时监测治疗反应的优势。尽管在将循环肿瘤细胞和无细胞DNA用于卵巢癌诊断方面已经取得了重大进展，但其早期检测或监测进展的潜力仍然难以捉摸。细胞外囊泡（EVs）是从几乎所有细胞类型释放的脂质膜颗粒的异质组。电动汽车包含蛋白质，mRNA，DNA片段，非编码RNA和脂质，并在细胞间通讯中起关键作用。新兴证据表明，电动汽车在癌症的发展和转移中起着至关重要的作用，从而为基于液体活检的卵巢癌诊断生物标志物发现提供了希望。在这篇综述中，我们讨论了基于EV的液体活检的优势，总结了从EV在卵巢癌中鉴定出的蛋白质生物标记，并重点介绍了最近开发的用于EV检测的新技术的实用性，重点是其在卵巢癌的诊断，监测中的应用。癌症进展，并开发个性化医学。

更新日期：2019-01-01

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