RNA-binding proteins (RBPs) are key regulators in post-transcriptional control of gene expression. Mutations that alter their activity or abundance have been implicated in numerous diseases such as neurodegenerative disorders and various types of cancer. This highlights the importance of RBP proteostasis and the necessity to tightly control the expression levels and activities of RBPs. In many cases, RBPs engage in an auto-regulatory feedback by directly binding to and influencing the fate of their own mRNAs, exerting control over their own expression. For this feedback control, RBPs employ a variety of mechanisms operating at all levels of post-transcriptional regulation of gene expression. Here we review RBP-mediated autogenous feedback regulation that either serves to maintain protein abundance within a physiological range (by negative feedback) or generates binary, genetic on/off switches important for e.g. cell fate decisions (by positive feedback).

中文翻译：

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RNA结合蛋白的自动调节反馈。

RNA结合蛋白（RBP）是基因表达的转录后控制中的关键调控因子。改变其活性或丰度的突变已涉及许多疾病，例如神经退行性疾病和各种类型的癌症。这突出了RBP蛋白稳定的重要性以及严格控制RBPs的表达水平和活性的必要性。在许多情况下，RBP通过直接结合并影响其自身mRNA的命运来参与自动调节反馈，从而控制其自身表达。为了进行这种反馈控制，RBP采用了多种机制在基因表达的转录后调控的所有水平上发挥作用。