One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi.,Clinical Infectious Diseases

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One-year Mortality Outcomes From the Advancing Cryptococcal Meningitis Treatment for Africa Trial of Cryptococcal Meningitis Treatment in Malawi.
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2020-01-16 , DOI: 10.1093/cid/ciz454
Cecilia Kanyama ₁ , Síle F Molloy ₂ , Adrienne K Chan _{3,

4} , Duncan Lupiya ₃ , Chimwemwe Chawinga ₁ , Jack Adams ₂ , Philip Bright _{3,

5} , David G Lalloo ₆ , Robert S Heyderman _{7,

8,

9} , Olivier Lortholary _{10,

11} , Shabbar Jaffar ₆ , Angela Loyse ₂ , Joep J van Oosterhout _{3,

8} , Mina C Hosseinipour _{1,

12} , Thomas S Harrison ₂

Affiliation

University of North Carolina Project-Malawi, Kamuzu Central Hospital, Lilongwe.
Centre for Global Health, Institute for Infection and Immunity, St George's University of London, United Kingdom.
Dignitas International, Zomba Central Hospital, Malawi.
Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
Clinical Immunology Department, North Bristol National Health Service Trust, United Kingdom.
Liverpool School of Tropical Medicine, United Kingdom.
Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre.
Department of Medicine, College of Medicine, University of Malawi, Blantyre.
University College London, United Kingdom.
Institut Pasteur, Molecular Mycology Unit, National Reference Center for Invasive Mycoses & Antifungals, Centre National de la Recherche Scientifique, Paris.
Paris Descartes University, Necker Pasteur Center for Infectious Diseases and Tropical Medicine, Institut Hospitalo-Universitaire Imagine, Assistance Publique - Hôpitaux de Paris, France.
Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill.

In Malawi, 236 participants from the Advancing Cryptococcal Meningitis Treatment for Africa trial were followed for 12 months. The trial outcomes reported at 10 weeks were sustained to 1 year. One-week amphotericin B plus flucytosine was associated with the lowest 1 year mortality (27.5% [95% confidence interval, 16.3 to 44.1]).

中文翻译：

推进隐球菌性脑膜炎治疗非洲试验的一年死亡率结果在马拉维进行隐球菌性脑膜炎治疗。

在马拉维，非洲隐球菌脑膜炎治疗试验的 236 名参与者接受了为期 12 个月的随访。10 周报告的试验结果持续至 1 年。1 周两性霉素 B 加氟胞嘧啶与最低的 1 年死亡率相关（27.5% [95% 置信区间，16.3 至 44.1]）。

更新日期：2020-01-16

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