We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.

中文翻译：

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布基纳法索学龄前儿童口服抗生素后肠道抵抗力：一项随机对照试验。

我们评估了全身抗生素（阿奇霉素、阿莫西林、复方新诺明或安慰剂）对 6 至 59 个月儿童肠道耐药组的影响。阿奇霉素和复方新诺明导致大环内酯类和磺胺类耐药决定因素增加。单一疗程的抗生素可诱导抵抗组扩张。