What is the best biological parameter to predict erectile dysfunction in men aged >55 years with type 2 diabetes?,Journal of Diabetes Investigation

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What is the best biological parameter to predict erectile dysfunction in men aged >55 years with type 2 diabetes?
Journal of Diabetes Investigation ( IF 3.1 ) Pub Date : 2019-07-08 , DOI: 10.1111/jdi.13089
Sitraka A Raharinavalona ₁ , Nicolas Chevalier ₂ , Claude Gruel ₁ , André-Christian N'toutoum ₁ , Fritz-Line Vélayoudom Céphise _{1,

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Affiliation

To date, there is no evidence regarding the best biological marker to predict erectile dysfunction (ED) in men aged >55 years with type 2 diabetes. This prospective study included data from men aged >55 years with type 2 diabetes. ED was assessed by the International Index of Erectile Function 15‐item survey. Total testosterone (TT) levels and bioavailable testosterone were measured; the free testosterone index was calculated. Data from 155 men (aged 64 ± 7 years) were explored. The prevalence of ED and testosterone deficiency was 78.7% and 34.8%, respectively. After univariate analysis, TT and bioavailable testosterone were associated with ED (P = 0.01). After multivariate analysis, and adjustment for age, body mass index, tobacco, alcohol, duration of diabetes, TT, bioavailable testosterone, vitamin D and high‐sensitivity C‐reactive protein, we found that only high‐sensitivity C‐reactive protein was significantly predictive of ED. TT could predict ED, but it lacks specificity. We found a potential role of high‐sensitivity C‐reactive protein as a predictive marker of ED in this targeted population.

中文翻译：

预测 55 岁以上 2 型糖尿病男性勃起功能障碍的最佳生物学参数是什么？

迄今为止，尚无证据表明预测 55 岁以上 2 型糖尿病男性勃起功能障碍 (ED) 的最佳生物标志物。这项前瞻性研究纳入了 55 岁以上患有 2 型糖尿病的男性的数据。 ED 通过国际勃起功能指数 15 项调查进行评估。测量总睾酮（TT）水平和生物可利用睾酮；计算游离睾酮指数。调查了 155 名男性（年龄 64 ± 7 岁）的数据。 ED 和睾酮缺乏的患病率分别为 78.7% 和 34.8%。经过单变量分析，TT 和生物可利用睾酮与 ED 相关（ P = 0.01）。经过多变量分析，并调整年龄、体重指数、烟草、酒精、糖尿病病程、TT、生物可利用睾酮、维生素 D 和高敏 C 反应蛋白，我们发现只有高敏 C 反应蛋白显着ED 的预测。 TT可以预测ED，但缺乏特异性。我们发现高敏 C 反应蛋白作为目标人群中 ED 的预测标记物具有潜在作用。

更新日期：2019-07-08

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