Hepatocellular carcinoma (HCC), the most common form of liver cancer, represents a health problem in hepatic viruses-eradicating era because obesity, type 2 diabetes, and nonalcoholic steatohepatitis (NASH) are considered emerging pathogenic factors. Metabolic disorders underpin mitotic errors that lead to numerical and structural chromosome aberrations in a significant proportion of cell divisions. Here, we review that genomically unstable HCCs show evidence for a paradoxically DNA damage response (DDR) which leads to ongoing chromosome segregation errors. The understanding of DDR induced by defective mitoses is crucial to our ability to develop or improve liver cancer therapeutic strategies.

肝细胞癌（HCC）是最常见的肝癌形式，代表着消除肝病毒时代的健康问题，因为肥胖，2型糖尿病和非酒精性脂肪性肝炎（NASH）被认为是新兴的致病因素。代谢紊乱是有丝分裂错误的基础，有丝分裂错误会导致很大比例的细胞分裂导致数字和结构染色体畸变。在这里，我们审查了基因组不稳定的肝癌显示出悖论性的DNA损伤反应（DDR）的证据，这导致了正在进行的染色体分离错误。对有缺陷的有丝分裂诱导的DDR的理解对于我们开发或改善肝癌治疗策略的能力至关重要。